Monday, December 31, 2012

Big Picture Thinkers And Silver | ZeroHedge

Recently I did a radio interview with longtime friend Al Korelin and blurted out that anyone who actively followed the gold/silver markets and did not appreciate how manipulated they are, was a moron. Not sure how that went over with Al?s listening audience, but I would like to parlay that comment here to deal with its significance.

You truly have to be mentally challenged if you follow the gold/silver market action and cannot appreciate something is very amiss, as per the confused Mitsui gold people, as brought to your attention the other day. There is NOTHING to be confused about. The more bullish the news for gold, the more reasons for the price to soar and the more The Gold Cartel deviants go into action to suppress both the gold and silver prices. How many times does the GATA camp have to point this out before the dingbats at Mitsui, and the rest of the mainstream gold world, will go there? The answer is infinity. These mainstream establishment gold pundits will NEVER tell their people the truth about what the gold market is all about. Hara-kiri
would be their first choice before telling the truth.

Most people naturally think the Mayans got it wrong about the world ending on December 21. Of course it is that way at first glance, but if what takes place in the economic/financial market arenas in the years ahead that I see coming, it might prove them correct in a way not commonly thought of (just a few years off and in a different articulation). Whatever is done with our fiscal cliff issue, it represents how incapable our politicians are of dealing with our mounting fiscal deficits and debt in America. It will not signify the end of the world, but could very well come to represent a moment when it becomes CLEAR our standard of living is going to significantly deteriorate ? and an end to a standard of living as we Americans have known it ... the end of that world. If the Mayans are correct in that regard, which I believe to be the case, the standard of living of most Americans, and others around the world, is going to change dramatically for the worse.

As this all kicks in, the realization of how broke the US is, along with many other nations, will take center stage. The understanding of the US money printing game will command the same attention on that stage. The dollar will begin its tapioca swan dive. Gold and silver will begin launches to doubling their prices for starters. The Gold Cartel will have to go into a retreat mode like we have not seen yet.

The Gold Cartel knows what is coming as presented above, which is why they have bombed gold and silver the past month+ when the fundamentals registered the most bullish factoids imaginable. PRICE ACTION MAKES MARKET COMMENTARY. The clueless (or disingenuous) out there in the mainstream gold world refuse to explain why the price of gold has behaved so counterintuitively ?, but the GATA camp will, and does, all the time.

Now, this is what I really want to get to ? in what I truly believe could be of meaningful support during this time of the investing public RUNNING AWAY FROM THE GOLD/SILVER/SHARE MARKETS, just when the focus should be on them the most! The bullish sentiment is really that bad.

To get right to the point, and to try and be of assistance, this is what I have done well at in the past ? getting into a major market move when few investors are paying attention to incredibly bullish fundamentals. That said, I am among THE WORLD?S WORST at dealing with market tops and taking profits. But, since we are dealing with major corrections in gold and silver, accompanied by dreadful bullish sentiment, that should not be of most concern at the moment.

SO, it is my opinion the prices of gold and silver are going to go into an EPIC move up stage, especially silver, next year. Silver will make all-time highs and be streaking for $100 an ounce. If there ever was a time to skew your investment portfolio towards silver, and pay extra attention, it is right now!

It is just human nature to NOT get it at market bottoms, or after significant corrections like we have just had, and to think out of the box. I was fortunate to have learned about all of this from three truly legendary financial market figures, and now there is a fourth. All of them understood true supply/demand numbers which were not appreciated by the investment world at the time. Each could spot a big picture trade and act on their knowledge way ahead of the pack. They were the smart ones, not me. I knew they knew what they were talking about with successful investment backgrounds to prove it. I listened to everything they had to say and learned from them what to spot and why, and then go with them.

I realize many veteran Caf? members know some of this and of those whom I am referring to, but it is worth repeating, right now, and focusing on just where we are after the recent Gold Cartel waterfall attacks. Each of these big picture thinkers could spot markets out of sync and knew how to take advantage of them and play for big money. They have been my mentors and are extraordinary individuals (what I cumulatively learned from them all those years I am hoping is indirectly passed on your way) ?.

*Daniel L. Ritchie

?

Daniel L. Ritchie became chairman and CEO of the Denver Center for the Performing Arts, one of the nation?s largest cultural complexes, in January 2007. He is the immediate past chairman of the Daniels Fund board, and is president of the Temple Hoyne Buell Foundation, which focuses on early childhood education and development.

Dan was chairman of the board of the University of Denver from 2005 to 2007, where he served as the university's sixteenth chancellor from 1989 until 2005. During his tenure, the DU pioneered the teaching of ethics at both the graduate and undergraduate levels. Chancellor Ritchie collaborated with Bill Daniels to incorporate ethics, values, and social responsibility throughout the business school curriculum. The business school was renamed Daniels College of Business in 1994 in honor of Bill Daniels.

In June 1994, Dan announced a personal gift to the university of $15 million, achieved through sale of some 19,600 acres of his Colorado ranch. Since then, he has given the university the remainder of the ranch, and its sale has netted more than $50 million for various projects?

?

?http://www.danielsfund.org/About-Us/Board-Bios/Daniel-Ritchie.asp

?

-END-

I met Dan at the New York Athletic Club in the mid 1970?s. We were in the gym lifting weights and he asked me about a pork belly quote, like in the Daily News, which was not there. What a nice man, I thought, and after taking a futures market class at the Cornell School of Hotel Administration, I thought why not go after what this seemingly bright man told me. I called my Merrill Lynch broker and bought a pork belly contract with a $500 margin requirement at the time. The first day after my broker put on my trade, I lost half my money. What a mistake I thought. Pork bellies went LIMIT UP the next nine out of ten days! I was hooked to go into the commodity futures industry. I asked Dan what I should do after a $4500 gain on a $500 investment in two weeks. I will never forget what he said, "Bill, you have done pretty well for your first trade, take those profits," which I did in a nanosecond. If I only had done that for the rest of my investment career!

Dan was very tied into the astute Refco operation out of Memphis, and made a fortune trading the cattle, hog and pork belly markets, with some great soybean trades thrown in there too.

?

I will never forget talking to Dan over a dinner when he was pondering whether to resign from Westinghouse Broadcasting, after being the number two guy under Lew Wasserman at MCA pictures, to run D.K. Ludvig?s empire. Ludvig was the richest man in the world at the time. And I will never forget that we flipped a coin to determine who would pay for dinner that night.

***

*Ray Dalio

Ray Dalio

Net Worth

$10 B As of September 2012

?

  • Founder & Co-Chief Investment Officer, Bridgewater Associates
  • Age: 63
  • Source of Wealth: hedge funds, self-made
  • Residence: Greenwich, CT
  • Country of Citizenship: United States
  • Education: Master of Business Administration, Harvard University; Bachelor of Arts / Science, Long Island University
  • Marital Status: Married
  • Children: 4

***

?

Ray is obviously a genius. Now famed CEO Sandy Weill didn?t think so when he fired Ray from his hedging director position at Shearson Hayden Stone in the mid 1970?s. Mr. Weill did not appreciate that, to make a hedging point, Ray brought in a girl with a fur coat on during a presentation of his in San Francisco. Her naked body was all that was left when Ray asked her to take off the coat.

So Ray started Bridgewater Associates. I had just joined Shearson and he needed someone to do a lot of grunt work for him. Many a night I took the subway from downtown Manhattan to midtown around 11:00. Ray got me going financially back then with his buy corn and feeder cattle futures and sell cattle futures when their margins were too fat. We did the reverse when they were too unprofitable. Made 100% on my money in days to weeks every time.

I know a number of you have seen this picture of Ray and me in Rio way back when, but it is too much fun to pass up here.

?

*Frank Veneroso

I was recruited to join the ill-fated Drexel Burnham on Park Avenue in 1980. That is where I met Frank as he was interested in buying bond futures when the interest rates were running up to 20%. He was early and took some hits, but then sold THE HIGH TICK after their first mega rally. I know, I did the trade. He made a killing.

Frank was known as a Wall Street Whiz Kid back then who was making money every year during the DOW dog days. He was then a consultant to a number of governments. One of my favorite financial stories ever is this one:

The Stock Market

Recollections of the Greatest Market Bubble Ever?


Memories of the Souk al Manakh

How large can a bubble grow before it bursts? Farther than you think. And there need not be a fatal pinprick that makes it burst. And when it bursts, the crash that ensues can be deeper and more discontinuous than you could ever imagine?

?

?http://www.lemetropolecafe.com/Pfv1.cfm?pfvID=454&SearchParam=Kuwait

?

-END-

Frank was commissioned by the World Bank to do a study on the copper market in 1986. Copper was nowhere back then, the price depressed to around 46 cents a pound. Frank was stunned to learn how bullish the fundamentals were because of the obvious demand which would be surfacing from Asia. FEW realized what was about to transpire, preferring to concentrate on the increasing importance of fiber optics. We muddled with the copper futures trade for a year. Then in May of 1987 there were no deliveries on the May contract. That was it I thought, the KEY to getting the trade right. I bought thousands of out of the money copper options. Copper went to $1.46 per pound by the end of the year, surviving the 1987 stock market crash in October of that year. I made $27 million on the trade and then found a way to blow a good deal of it. But, being Jackie Onassis?
neighbor in Bernardsville, N.J. for a couple of years is still a fond memory.

***

All of that brings me to where we are today and the reason I would like to make a commotion out of this commentary?

*Eric Sprott

Eric, who is one of GATA?s most ardent supporters, is one of the nicest guys you will ever meet and a true genius. As my good friend John Embry (brilliant in his own right) has told me for years, Eric is the best student of supply/demand dynamics he has ever come across. His presentation at the Dos Passos Table is just one example of what John is referring to.

Eric has been jumping up and down about the price of silver?s potential for many years now and was very visible at certain conferences not that long ago when the price was $14/16 an ounce. He has been all over the place this year talking to investors about what he thinks the price of silver is going to do and why. Eric has publicly stated silver is going to $100 per ounce and higher. He is my anchor when I pound the table about silver ? that same anchor of formidable insight I learned so long ago from the likes of Dan Ritchie, Ray Dalio, and Frank Veneroso. It is not me you need to pay attention to, but Eric!

I don?t need to be able to break down the supply/demand numbers like Eric has done; and like Dan, Ray and Frank have done for so many years. I know they know what they are talking about. What I can bring to the table is an appreciation of just how much gold and silver have been manipulated, and orchestrated down to artificially low prices, which will not stand in the years ahead. JP Morgan, and others suppressing the price, has to be close to being forced into backing off. Their use of derivatives to suppress the price in the face of an extremely tight physical market ought to be very close to having run its course. Knowing what we know in the GATA camp about what JP Morgan has done will prove to be invaluable in the months and years ahead. No one knows that more than Eric.

The investment opportunity of a lifetime is staring us in the face and not that many investors out there get it. Eric does and he has backed it up publicly with his investments: his ETF (PHYS) is an example. Fortunes will be made in silver over the years ahead for those willing to do their homework and take a plunge ? and that will be most true in the silver shares whose firms have the goods in the ground.

Investing in many of the junior/exploration stocks in the gold/silver sector has been a horror show these last years. While I have been so right about gold and silver for the past 12 years, my second biggest investment mistake ever was not to take profits around 2008 with my share selections when the legendary Bob Bishop told the attendees at GATA Goes To Washington conference in April of 2008 that the move up in the gold/silver shares was over for the time being. As you may know, Bob is going to let his latest thoughts known at GATA?s fundraiser in Vancouver on January 21 at the Pan Pacific Hotel following the Cambridge House conference.

BUT, as bad as the junior/exploration sector has been in recent years, it will be that good by double or triple, or much more, in the years ahead. Think NEWTON?S LAW!

Silver is on its way next year to $100 per ounce. You want to bet against Eric Sprott? And that is the reason for this special commentary. Ritchie, Dalio, and Veneroso are true legends in the futures trading arena, and in the making big money in the markets arena. So is Eric. Keep that in mind and spread the word.

While the standard of living in America and other places is likely to deteriorate significantly in the years ahead, those who have stayed with various gold/silver investments ought to be happy campers. Should that Mayan prediction be all about a drastic change in our standard of living as we have known it (the end of that world), owning silver and the silver shares in the years ahead will be a counter to some darker times on the horizon.

?

Bill Murphy

www.lemetropolecafe.com

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Source: http://www.zerohedge.com/contributed/2012-12-30/big-picture-thinkers-and-silver

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Kardashian, West feel 'blessed' over baby news

ATLANTIC CITY, N.J. (AP) ? Kim Kardashian and Kanye West are feeling lucky about their first child together.

"It's true," the 32-year-old reality TV star said in a statement on her site Monday. "Kanye and I are expecting a baby. We feel so blessed and lucky and wish that in addition to both of our families, his mom and my dad could be here to celebrate this special time with us."

Kardashian's father, Robert Kardashian, died in 2003. West's mother, Donda West, died in 2007.

Kardashian added in the blog post that she was "looking forward to great new beginnings in 2013 and to starting a family."

The 35-year-old rapper revealed to a crowd of more than 5,000 in song form at a concert Sunday that his girlfriend is pregnant. Kardashian was in the crowd at Revel Resort's Ovation Hall with her mother, Kris Jenner, and West's mentor and best friend, Jay-Z.

The news instantly went viral online, with thousands posting and commenting on the expecting couple.

Most of the Kardashian clan tweeted about the news, including Kim's sisters. Kourtney Kardashian wrote: "Another angel to welcome to our family. Overwhelmed with excitement!"

West told concertgoers to congratulate his "baby mom" and that this was the "most amazing thing."

Representatives for West and Kardashian didn't immediately respond to emails about the pregnancy.

The rapper and reality TV star went public with their relationship in March.

Kardashian married NBA player Kris Humphries in August 2011 and their divorce is not finalized.

West's Sunday-night show was his third consecutive performance at Revel. He took the stage for nearly two hours, performing hits like "Good Life," ''Jesus Walks" and "Clique" in an all-white ensemble with two bandmates.

Kardashian is expected to spend New Year's Eve at public appearance at a Las Vegas nightclub.

___

AP Writer Bianca Roach contributed to this report.

___

Follow Mesfin Fekadu on Twitter at http://twitter.com/MusicMesfin . Follow Bianca Roach at http://twitter.com/B__Roach

Source: http://news.yahoo.com/kardashian-west-feel-blessed-over-baby-news-190710588.html

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NBA: Milwaukee Bucks rally to blow Heat off the floor

The Milwaukee Bucks stunned the Miami Heat with a fourth-quarter blitz on Saturday to record a 104-85 blowout win over the NBA champions.

With the Heat leading 71-69 entering the final period, the Bucks (16-12) kicked into high gear and outscored Miami 35-14 to blow them off the floor in the last quarter.

Brandon Jennings scored 25 points, Mike Dunleavy scored 13 of his 18 in the fourth and Milwaukee forced Miami into errors and turnovers. It was Miami?s second successive loss.

?It was good to win a game like this against the defending champs,? Milwaukee?s Luc Richard Mbah a Moute told reporters. ?We?ve got to enjoy this one and continue to go at it. We needed to win a couple of games in a row at home.?

Heat guard Dwyane Wade returned from his one-game suspension for kicking Charlotte?s Ramon Sessions and scored 24 points, while LeBron James added 26 points.

Milwaukee had jumped out to a 56-44 halftime lead, but gave the advantage back in the third, where James took over and the Heat outscored them 27-13 in the quarter.

James had 14 in the third to pull his team back in the game.

However, everything changed in the fourth as Larry Sanders and Moute both produced two blocks each in the first few minutes to fuel a stirring run for the home side.

Playing in front of a boisterous crowd, the Bucks scored the first nine points of the fourth and never looked back.

?It?s always been tough for us to play them,? Wade said. ?It?s always a battle. They did their job and used their energy in the fourth quarter. They took a lead and we couldn?t come back.?

Moute finished with 19 points and Sanders had 16 and 11 rebounds.

It was a rare off night for the Heat, who just missed tying their season-low point total of 84 and got little help from their supporting cast.

Both James and Wade made more than half of their field goal attempts and Chris Bosh (12 points) was the only other player to reach double figures.

Thunder 124, Rockets 94

In Houston, Russell Westbrook scored 28 points and Kevin Durant added 26 as the Oklahoma City Thunder built a big lead in the second quarter and rolled to a 124-94 win over the Houston Rockets on Saturday night.

Durant scored 11 points during a 16-0 run by the Thunder to end the first half and extend the lead to 18. Oklahoma City had another big run early in the third quarter to put the game further out of reach.

Former Thunder sixth man James Harden scored 25 for the Rockets, who went cold on offense for long stretches.

It was Oklahoma City?s second win this season over Houston, after taking the first meeting 120-98.

Kevin Martin, who came to Oklahoma City in the trade for Harden, finished 19 points and five three-pointers. Westbrook had eight rebounds and eight assists.

Marcus Morris scored a career-high 24 points for Houston.

Hornets 98, Bobcats 95

In Charlotte, Eric Gordon had 24 points and seven assists, helping New Orleans overcome a 21-point first-half deficit and extend Charlotte?s losing streak to 18 games.

The Bobcats are one game away from a winless month this month. They have not won since Nov. 24.

Gordon, who had not played since April 22 following arthroscopic right knee surgery, was five of 13 from the field and 12 of 14 from the free-throw line in 24 minutes.

Ryan Anderson had 19 points and made a pair of three-pointers in the final period as the Hornets won for the second time in three games.

Source: http://libertytimes.feedsportal.com/c/33098/f/535602/s/270edc76/l/0L0Staipeitimes0N0CNews0Csport0Carchives0C20A120C120C310C20A0A355140A1/story01.htm

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Sunday, December 30, 2012

E-WebStyle SEO Podcast - Awesome! - UK Business Forums

Does anyone else listen to this podcast on itunes? I really think anyone interested in SEO HAS to listen to it! I've learnt more listening to this regularly than reading any ebooks etc

Just search for SEO podcast on itunes and its the top rated one.

I'm in no way associated to this btw! Just love the podcast and feel it needs to be heard by all, pretty damm funny as well.

xx
Amy

Source: http://www.ukbusinessforums.co.uk/forums/showthread.php?t=282172

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Cassie Jones is watching Community

Sorry, Readability was unable to parse this page for content.

Source: http://getglue.com/conversation/cassie_jones/2012-12-30T15%3A53%3A19Z

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President Obama pushes for gun law passed in 2013

December 30, 2012 - 09:12 am

WASHINGTON (AP) - Recalling the shooting of 20 first graders as the worst day of his presidency, President Barack Obama on Sunday pledged to put his "full weight" behind a legislative package next year aimed at containing gun violence.

In an interview with NBC's "Meet the Press," Obama voiced skepticism about proposals to place armed guards at schools in the aftermath of the Dec. 14 deadly assault at Sandy Hook Elementary School in Newtown, Conn.

In his boldest terms yet, he vowed to rally the American people around an agenda to limit gun violence and said he still supports increased background checks and bans on assault weapons and high capacity bullet magazines.

"It is not enough for us to say, 'This is too hard so we're not going to try,'" Obama said. "So what I intend to do is I will call all the stakeholders together. I will meet with Republicans. I will meet with Democrats. I will talk to anybody. "I think there are a vast majority of responsible gun owners out there who recognize that we can't have a situation in which somebody with severe psychological problems is able to get the kind of high capacity weapons that this individual in Newtown obtained and gun down our kids. And, yes, it's going to be hard."

Obama's comments come as the schoolroom shooting has elevated the issue of gun violence to the forefront of public attention. Six adults also died at the school.

Authorities say the shooter killed himself and his mother at their home. The slayings have prompted renewed calls for greater gun controls.

The National Rifle Association has resisted those efforts vociferously, arguing instead that schools should have armed guards for protection.

"I am skeptical that the only answer is putting more guns in schools," Obama said. "And I think the vast majority of the American people are skeptical that that somehow is going to solve our problem."

Obama said he intended to press the issue with the public.

"Will there be resistance? Absolutely there will be resistance," he said. "The question then becomes whether we are actually shook up enough by what happened here that it does not just become another one of these routine episodes where it gets a lot of attention for a couple of weeks and then it drifts away. It certainly won't feel like that to me. This is something that - you know, that was the worst day of my presidency. And it's not something that I want to see repeated."

Besides getting gun violence legislation passed next year, Obama also listed immigration as a top priority for 2013 as well as deficit reduction.

A big deficit reduction deal with Republicans proved elusive this month and Obama is now hoping Senate Democratic and Republican leaders salvage a scaled back plan that avoids across the board tax increases for virtually all Americans.

He issued a defense of former Republican Sen. Chuck Hagel of Nebraska, who has been mentioned as one of the leading candidates for new secretary of defense.

Hagel, who opposed President George W. Bush's decision to go to war with Iraq, has been criticized in conservative circles for not being a strong enough ally of Israel.

Many liberals and gay activists also have banded against him for comments he made in 1998 about an openly gay nominee for an ambassadorship Obama, who briefly served with Hagel in the Senate, stressed that he had yet to make a decision on a secretary of defense but said called Hagel a "patriot."

"He is somebody who has done extraordinary work both in the United States Senate," he said. "Somebody who served this country with valor in Vietnam. And is somebody who's currently serving on my intelligence advisory board and doing an outstanding job."

He noted that Hagel had apologized for his 14-year-old remark.

"And I think it's a testimony to what has been a positive change over the last decade in terms of people's attitudes about gays and lesbians serving our country," Obama said.

Source: http://www.wjla.com/articles/2012/12/president-obama-says-he-s-been-fair-in-cliff-talks-83550.html

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Saturday, December 29, 2012

Web Hosting An Information For Newcomers | The Floor Geek

The entire process of developing a website and obtaining it internet may be a tricky 1, in particular for that non-technical local community. And this unquestionably isn?t helped by normal false impression that domain registration and web site internet hosting is one particular together with the exact issue.

So let us clear things up. Domain registration and online web hosting are two separate processes, equally of which ought to be done if you want to produce a web site and allow it to be dwell on-line.

Set simply just the procedure is as follows: a website has to be registered by a site registration supplier and then that domain title needs to be hosted using the net via a web internet hosting enterprise.

And here is whereby the confusion is available in. Scores of businesses will offer you both domain registration and website internet hosting, while people will only have both world-wide-web internet hosting or domain registration. For these reasons it is easy to decide to sign-up your domain and host your internet site when using the similar specialist or register your domain with one company and host your internet site with one other.

It realistically so simple as that, but is a thing that triggers a good deal of confusion and unneeded worry to a great many most people seeking to set up a website.

Domain Registration
To utilise the net to speak with other folks or to glance up help and advice, you could have to form an deal with into your personal machine. These addresses are really a name or perhaps number and therefore are far more frequently well-known as domains. Each and every domain name needs to be 100 % completely unique so that the net has learned the correct webpage to carry up for your person.

If you decide to choose to formulate your own private blog, you ought to devise a reputation you wish your web site for being recognised as. This identify then must have to generally be registered using a domain registration supplier to make certain that it?s unique which you become the legal operator of that domain name.

Additionally you really should decide a site extension to attribute to the domain identify. By this we suggest.com,.co.united kingdom,.org,.web and so forth. You will need to give very careful thing to consider towards the domain extension you end up picking in order that your extensive domain name finest signifies that within your online business or task. By way of example once you are really an Uk online business and so are only marketing towards British isles, it might be only to settle on a.co.united kingdom domain extension ? notably for obtaining ideal Uk search engine rankings.

It really is crucial that ahead of registering a site identify accompanied by a domain registrar that you simply take a look at that they?re a credible domain registration organization. A single method of executing this is often to look at the domain registrar?s website is featured to the ICANN (The internet Corporation for Assigned Names and Figures) Accredited Registrars listing

Web hosting
Once you have registered your one-of-a-kind domain name with the accredited domain registrar, it?s good to get your website stay on the net. To attempt this, you need to actually buy a web hosting package from an internet hosting supplier.

The whole process of placing your internet site using the web is concluded by the world wide web web hosting service you indicator up with and will involve positioning your internet site on a website server that is certainly then joined into the online. The kind of world-wide-web server your internet site is hosted on will rely on the specifications of one?s webpage. Just about the most very common word wide web hosting plans are Shared Word wide web Internet hosting and Committed Server Online Hosting.

Shared Word wide web Web hosting
For those who have a very very easy internet site which requires a consistent amount of online place and bandwidth, then it?s probably that the hosting provider recommend you decide on a shared web site internet hosting schedule.

With this regimen your site will be placed on among the net internet hosting firm?s shared online servers. Below your website will reside along with many other very similar sized websites whereby it can reveal all of the server?s sources and qualities.

Each individual internet hosting organization differs within the hosting functions they supply with their shared hosting ideas. With a great deal of online businesses you should obtain as traditional:

oA specified volume of world-wide-web space subject to your chosen package
oEasy to apply world-wide-web information site user interface
oOnline account administration center
oFull 24/7 ftp access to add your website information
oFree domain transfer
oUnlimited domain aliases
oWebmail
oSend and obtain e-mail utilizing Microsoft Outlook or any other electronic mail plans

Focused Server World wide web Web hosting
If the websites is continuing to grow into a measurement which is unable to be accommodated on a shared server or those that need the flexibility to add program or another abilities for your internet site, then your world wide web web hosting provider might advocate you buy a devoted server.

Which includes a devoted server, you own the legal rights with the full server; thus offering you entire regulate in excess of exactly what is put in and operate on the server. House and bandwidth utilization will even not any longer be considered a difficulty as there will only be your web site (or web sites) using the servers means.

Having a devoted server you also have peace of mind that the blog(s) won?t be on the mercy of other webpages along with their perhaps corrupt code ? which could produce downtime together with other dilemmas for your site.

When picking a focused server you may opt to own your server managed or unmanaged because of the online internet hosting small business. By having a managed server, it?s possible you?ll get products and services most notably internet page administration, selected software application installation, servicing and upgrades. The foremost moreover of having your dedicated server managed is the fact that you?ve got an authority on hand will ideally your server suffer any failure ? guaranteeing your internet site a very high uptime proportion. Even though substantially more affordable, unmanaged server hosting is simply incredibly advocated for anyone having a substantial diploma of technical information in server administration and administration.

Advantages Of Semi Dedicated Internet Hosting can provide you with highest facts for Datacenter High 5 Reasons Why Data Heart In North America Is The Best In Internet Hosting.Please be sure to drop by and see the published article for more data!

Related posts:

  1. Main Companies Provided By The Net Hosting Companies
  2. Internet Hosting An Information For Newcomers
  3. Internet Hosting An Information For Inexperienced Persons
  4. A Laymans Guide To Web Hosting And Servers
  5. What?S Collocation Is The Colocation Technology Is Finest For Web Hosting

Source: http://www.thefloorgeek.com/2012/12/web-hosting-an-information-for-newcomers/

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What is VoIP Service - Basic Features

what is voip

One of the most popular technological advancement nowadays is the Voice over Internet Protocol VoIP, which is being used by both small business and large corporations alike. For many business owners, Internet Protocol (IP) is not just a toll to communicate but it also makes a wide range of business applications much simpler, more structured and efficient. Telephony is the most apparent example. Moreover, VoIP initiated the trend of advanced integrated communications applications including those that can transform your business like online and video conferencing.

Ordinary consumers use the Internet to connect public Internet phone calls. However, business enterprises and companies choose to have their own IP telephony system for their own private networks in order to ensure security and service quality of communication. Having their own private networks will give companies the control when it comes to technical things such as voice quality. They will be able to give better services than they would have previously given with their traditional phone system.

Given how important modern telephony is, Erica Bell of TechRepublic enumerated the must-have features a VoIP system. A good communication system is without a doubt an element to the success of a business. Whether it is a small business or a large corporation, all business owners would want to be able to manage its affairs in the most efficient and effective way possible. With the right features, VoIP can make that happen. According to Bell, beyond the basics of voicemail number, here are the best features to consider when choosing a VoIP plan.

  • Call routing and forwarding is basic and should not be discarded. Depending on the plan chosen by the business owner, this feature can support remote access and it allows employees to efficiently communicate with each other whether they may be in the office, at home, or on the road. A Skype, AT&T or?RingCentral voicemail number?even have special features which forwards messages to emails and phones.
  • Some businesses make it a point to go the extra mile. They have a system called customer relationship management or the CRM which they use to improve their efficiency. These companies make in bound call screens. This is one way of showing to customers that the latter are being prioritized by the former.
  • Arguably, the most important feature of Voice over Internet Protocol is its ability to conduct conference calls. Many VoIP providers offer business telephone systems which has features that will allow instant call conferencing as well as video and online conferencing.

Bell in her conclusion, takes time to remind business owners and entrepreneurs to consider all the important factors that their business telephone must possess. With the number of VoIP providers out there, they must pick one which suits the nature of their business the best. While there are phone service providers that will allow the business to keep their current phone plans, others may require the use of Internet protocol phones.

For companies, VoIP is the best option because owners and entrepreneurs will be able to eliminate traditional phone system with a single network and at the same time consolidate business utilities in order to give better services to customers and clients.

Author?s Bio:

Henry Conrad is a 29-year-old game developer from Albuquerque, New Mexico. Aside from gaming and being a tech junky, he also dabbles in creative writing, which allows him to create great storylines and backgrounds for his characters. Follow me on Twitter and join me in Google +.

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Source: http://www.goharsh.com/cell-phone/what-is-voip-service-basic-features/

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China tightens Internet controls, legalizes post deletion

5 hrs.

China unveiled tighter Internet controls on Friday, legalizing the deletion of posts or pages which are deemed to contain "illegal" information and requiring service providers to hand over such information to the authorities for punishment.

The rules signal that the new leadership headed by Communist Party chief Xi Jinping will continue muzzling the often scathing, raucous online chatter in a country where the Internet offers a rare opportunity for debate.

The new regulations, announced by the official Xinhua news agency, also require Internet users to register with their real names when signing up with network providers, though, in reality, this already happens.

Chinese authorities and Internet companies such as Sina Corp have long since closely monitored and censored what people say online, but the government has now put measures such as deleting posts into law.

"Service providers are required to instantly stop the transmission of illegal information once it is spotted and take relevant measures, including removing the information and saving records, before reporting to supervisory authorities," the rules state.

The restrictions follow a series of corruption scandals amongst lower-level officials exposed by Internet users, something the government has said it is trying to encourage.

Li Fei, deputy head of parliament's legislative affairs committee, said the new rules did not mean people needed to worry about being unable to report corruption online. But he added a warning too.

"When people exercise their rights, including the right to use the Internet, they must do so in accordance with the law and constitution, and not harm the legal rights of the state, society ... or other citizens," he told a news conference.

Chinese Internet users already cope with extensive censorship measures, especially over politically sensitive topics like human rights and elite politics, and popular foreign sites Facebook, Twitter and Google-owned YouTube are blocked.

Earlier this year, the government began forcing users of Sina's wildly successful Weibo microblogging platform to register their real names.

The new rules were quickly condemned by some Weibo users.

"So now they are getting Weibo to help in keeping records and reporting it to authorities. Is this the freedom of expression we are promised in the constitution?" complained one user.

"We should resolutely oppose such a covert means to interfere with Internet freedom," wrote another.

The government says tighter monitoring of the Internet is needed to prevent people making malicious and anonymous accusations online, disseminating pornography and spreading panic with unfounded rumors, pointing out that many other countries already have such rules.

Despite periodic calls for political reform, the party has shown no sign of loosening its grip on power and brooks no dissent to its authority.

(Reporting by Ben Blanchard and Sally Huang; Editing by Nick Macfie)

(c) Copyright Thomson Reuters 2012. Check for restrictions at: http://about.reuters.com/fulllegal.asp

Source: http://www.nbcnews.com/technology/technolog/china-tightens-internet-controls-legalizes-post-deletion-1C7755876

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Friday, December 28, 2012

German finance minister says worst of euro debt crisis over | The ...

German finance minister says worst of euro debt crisis over

First Published Dec 27 2012 09:44 am ? Last Updated Dec 27 2012 09:44 am

Berlin ? Germany?s finance minister says the worst of euro area?s debt crisis appears to be over after three years of worries over Greece and other members of the group of 17 European Union countries that use the single currency.

Finance Minister Wolfgang Schaeuble was quoted Thursday as telling the Bild newspaper: "I think we have the worst behind us."

Schaeuble says Greece and others have recognized that they can only overcome the crisis by implementing reforms and that the Greek government ? which has received two bailouts ? "knows that it cannot financially overburden the other euro states".

Some in Germany have expressed concern about the economy of neighboring France. But Schaeuble says the government there "knows very well that every country must constantly conduct reforms to remain competitive."


Copyright 2012 The Salt Lake Tribune. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Source: http://www.sltrib.com/sltrib/money/55533129-79/says-crisis-euro-worst.html.csp

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Fiscal Cliff Talks: Obama To Meet With Senate GOP Friday

  • Military Health Care - $16 Billion

    In his last offer to House Speaker John Boehner (R-Ohio), President Barack Obama lobbied for $16 billion in cuts from the military's health care program, TRICARE. In 2012, the president also proposed hiking fees for military personnel and veterans who receive benefits under the program in an effort to help cut the defense budget. His proposal drew significant fire from Republican lawmakers and veterans' groups.

  • Military Retirement Program - $11 Billion

    Both sides agreed to cuts from the military retirement program. Rep. Eric Cantor (R-Va.) claimed during July 2011 talks that lawmakers had reached a tentative deal to slash <a href="http://www.huffingtonpost.com/2012/11/11/fiscal-cliff-talks-medicare-social-security_n_2113259.html" target="_hplink">$11 billion</a>. Under the current system, military personnel receive immediate retirement benefits after serving for 20 years. According to a recent report from the Congressional Budget Office, the appropriation cost per active military service member has <a href="http://www.cbo.gov/publication/43574" target="_hplink">increased at a higher rate</a> than either inflation or the total pay package of private-sector employees. Given the budget constraints looming before the Defense Department, the CBO floated the idea of transitioning the military retirement program to a matching-payment model.

  • Federal Employee Retirement Program - $33 -$36 Billion

    Cantor claimed that Republicans and Democrats had agreed to <a href="http://www.huffingtonpost.com/2012/11/11/fiscal-cliff-talks-medicare-social-security_n_2113259.html" target="_hplink">$36 billion in savings</a> over 10 years from civilian retirement programs. The president proposed a marginally more modest figure of <a href="http://presspass.nbcnews.com/_news/2012/11/11/15089281-white-house-grand-bargain-offer-to-speaker-boehner-obtained-by-bob-woodward#.UKCJftkTtS8.twitter" target="_hplink">$33 billion</a> in his final offer to House Speaker John Boehner. Just this year, Republicans in the House Committee on Oversight and Government Reform also looked to find savings from the Federal Employee Retirement System by <a href="http://www.washingtonpost.com/blogs/federal-eye/post/house-committee-approves-measure-upping-federal-employee-contributions-to-retirement-plan/2012/04/26/gIQAuoW6iT_blog.html" target="_hplink">requiring employees to pay more of their salary</a> into their pensions, which Democrats opposed as a pay cut that would make civil service less attractive for top talent. In September 2011, the federal government employed <a href="http://www.fedscope.opm.gov/cognos/cgi-bin/ppdscgi.exe?DC=Q&E=/FSe%20-%20Status/Employment%20-%20September%202012&LA=en&LO=en-us&BACK=/cognos/cgi-bin/ppdscgi.exe?toc=%2FFSe%20-%20Status&LA=en&LO=en-us" target="_hplink">over two million individuals</a>, either through the cabinets or independent agencies. Many Republicans have complained that the federal workforce has ballooned during the Obama administration, and while the raw number of employees has risen by <a href="http://www.thefactfile.com/2012/01/23/the-size-of-the-federal-workforce-rapid-growth-for-some-stagnation-for-others/" target="_hplink">14.4 percent</a> between Sept. 2007 and Sept. 2011, the percentage of public employees out of the total civilian workforce has <a href="http://www.thefactfile.com/2012/01/23/the-size-of-the-federal-workforce-rapid-growth-for-some-stagnation-for-others/" target="_hplink">remained fairly constant</a> around 1.2 percent since 2001. Much of the raw growth has been concentrated in the Department of Defense, Veteran's Affairs and Homeland Security.

  • Agricultural Subsidies - $30 - $33 Billion

    Democrats and Republicans agreed to cut as much as <a href="http://www.huffingtonpost.com/2012/11/12/fiscal-cliff-barack-obama-_n_2118739.html" target="_hplink">$30 billion</a> from agricultural subsidies; the main opposition fell along geographical lines rather than partisan ones. Hailing from an agriculture-heavy state, Sen. Max Baucus (D-Mont.) threatened to pull out of talks entirely if a deal included that much in subsidy reduction. The president ended up pushing for <a href="http://www.huffingtonpost.com/2012/11/11/fiscal-cliff-talks-medicare-social-security_n_2113259.html" target="_hplink">$33 billion in cuts</a>, but that figure also included reductions in conservation programs. Baucus now tells HuffPost any cuts should be made through the farm bill, not fiscal cliff talks.

  • Food Stamps - $2 to $20 Billion

    Cantor pushed hard for significant cuts to food stamps, formally known as the Supplemental Nutrition Assistance Program. He charged that the federal government could save as much as <a href="http://www.huffingtonpost.com/2012/11/11/fiscal-cliff-talks-medicare-social-security_n_2113259.html" target="_hplink">$20 billion over ten years</a> by eliminating waste and fraud, but the White House countered that the real number was closer to $2 billion. Instead, those cuts would force the program to scale back on the number of enrollees and the level of benefits it could offer.

  • Flood Assistance - $4 Billion

    Obama proposed cutting <a href="http://www.huffingtonpost.com/2012/11/12/fiscal-cliff-barack-obama-_n_2118739.html" target="_hplink">$4 billion from flood assistance</a> funding in his final offer to Boehner in July 2011. But Hurricane Sandy straining the National Flood Insurance Program; The New York Times <a href="http://www.nytimes.com/2012/11/13/nyregion/federal-flood-insurance-program-faces-new-stress.html?pagewanted=all&_r=0" target="_hplink">reports</a> that thousands of claims are being submitted daily, which could send the overall cost upwards of $7 billion for a program that suffers from a ballooning debt problem. And with climate change promising <a href="http://www.washingtonpost.com/blogs/capital-weather-gang/post/climate-change-predictions-foresaw-hurricane-sandy-scenario-for-new-york-city/2012/10/31/b78de428-2374-11e2-ac85-e669876c6a24_blog.html" target="_hplink">future flooding disasters</a> along the eastern seaboard, cutting the program looks unwise.

  • Home Health Care - $50 Billion

    The president offered to cut <a href="http://presspass.nbcnews.com/_news/2012/11/11/15089281-white-house-grand-bargain-offer-to-speaker-boehner-obtained-by-bob-woodward#.UKCJftkTtS8.twitter" target="_hplink">$110 billion over the next decade</a> from the government's health care spending, excluding Medicare. Among the programs that could lose crucial funding is home health care, where Democrats and Republicans agreed to <a href="http://www.huffingtonpost.com/2012/11/11/fiscal-cliff-talks-medicare-social-security_n_2113259.html" target="_hplink">$50 billion in reductions</a> over ten years. Cantor pushed for closer to $300 billion in spending cuts to health care, but Democrats appeared to stand firm.

  • Higher Education - $10 Billion

    The president proposed cutting <a href="http://www.huffingtonpost.com/2012/11/12/fiscal-cliff-barack-obama-_n_2118739.html" target="_hplink">$10 billion from higher education</a> over the next decade, mostly from Pell grants. <a href="http://www.huffingtonpost.com/2012/08/27/pell-grants-college-costs_n_1835081.html" target="_hplink">Over nine million students</a> relied on federal subsidized loans to afford college during the 2010-2011 school year, and the skyrocketing costs have continued to diminish the purchasing power of the Pell grant program. Obama has actively worked to make college more affordable for lower-income students. Key Republican lawmakers have attempted to cut funding for student loans; most notably, Rep. Paul Ryan (R-Wis.) slashed the maximum award from $5,550 per student per year down to <a href="http://colorlines.com/archives/2011/07/dems_students_fight_to_save_pell_grants_amidst_debt_ceiling_talks.html" target="_hplink">just $3,040</a>.

  • Medicaid And Other Health- $110 Billion

    The original funding levels proposed by Cantor and the GOP leadership would turn the entitlement program for America's poor into little more than a block grant program, Democrats claimed during the 2011 debt ceiling talks. Under such a program, they argued that states would then <a href="http://www.bloomberg.com/news/2012-09-11/medicaid-to-lose-1-26-trillion-under-romney-block-grant.html" target="_hplink">drop more people from enrollment</a> and scale back on health benefits. In fiscal year 2009, <a href="http://www.census.gov/compendia/statab/2012/tables/12s0151.pdf" target="_hplink">over 62 million Americans</a> -- many of them children -- depended on Medicaid for their health care. But the president did agree to <a href="http://presspass.nbcnews.com/_news/2012/11/11/15089281-white-house-grand-bargain-offer-to-speaker-boehner-obtained-by-bob-woodward#.UKCJftkTtS8.twitter" target="_hplink">$110 billion</a> in cuts from Medicaid and other health programs.

  • Medicare - $250 Billion +

    Republicans pushed for a drastic overhaul to the entitlement program for America's seniors. Ryan infamously proposed turning Medicare into little more than a voucher system in which seniors would receive checks to purchase their own health care on the open market -- a plan that would ultimately <a href="http://www.huffingtonpost.com/kennethdavis/medicare-vouchers_b_1947804.html" target="_hplink">force individuals to shoulder more of the burden</a> for their health care costs. Democrats refused to accept changes similar to those in Ryan's plan. The president, however, was <a href="http://www.huffingtonpost.com/2012/11/11/fiscal-cliff-talks-medicare-social-security_n_2113259.html" target="_hplink">more open to other GOP suggestions</a> on Medicare. In his final offer to Boehner, he agreed cut $250 billion over the next ten years -- in part by increasing premiums for higher-income seniors and by raising the eligibility age from 65 to 67 (although over a longer time frame).

  • Tax Reform - $800 Billion - $1.6 Trillion

    Republicans have again and again <a href="http://www.politico.com/blogs/politicolive/0511/Boehner_Medicare_Medicaid__everything_should_be_on_the_table_except_raising_taxes.html" target="_hplink">decried any attempt</a> to raise taxes, either on the highest earners or on corporations. (A Democracy Corps/Campaign for America's Future survey shows that <a href="http://www.ourfuture.org/report/2012114508/cafdemocracy-corps-election-poll-2012" target="_hplink">70 percent of voters</a> support raising taxes on the wealthiest two percent of Americans.) Instead, Boehner has pushed for a <a href="http://www.huffingtonpost.com/2012/11/11/fiscal-cliff-talks-medicare-social-security_n_2113259.html" target="_hplink">comprehensive tax reform bill</a> that would lower the marginal tax rates while closing loopholes and eliminating deductions in order to raise around $800 billion in additional revenues. For many Democrats, <a href="http://online.wsj.com/article/SB10001424127887323551004578117152861144968.html" target="_hplink">that figure simply isn't enough</a>. White House Press Secretary Jay Carney announced Tuesday that the president was aiming for as much as <a href="http://takingnote.blogs.nytimes.com/2012/11/13/showing-backbone-on-the-debt/" target="_hplink">$1.6 trillion in new revenues</a>, and the president told reporters on Wednesday that it would be <a href="http://www.huffingtonpost.com/2012/11/14/obama-tax-cuts_n_2131256.html" target="_hplink">practically impossible</a> to raise the amount of revenue he wanted simply from closing loopholes and lowering rates.

  • Social Security - $112 Billion

    Social Security <a href="http://www.huffingtonpost.com/2012/11/14/fiscal-cliff-social-security_n_2130762.html?utm_hp_ref=mostpopular" target="_hplink">isn't driving the deficit</a>, yet Republicans have <a href="http://www.huffingtonpost.com/2012/11/11/fiscal-cliff-talks-medicare-social-security_n_2113259.html" target="_hplink">pursued drastic changes</a> to the program. Sen. Harry Reid (D-Nev.) has promised that Social Security would be <a href="http://livewire.talkingpointsmemo.com/entry/reid-no-messing-with-social-security" target="_hplink">off the table</a> in the on-going negotiations to avoid the fiscal cliff, but Obama did concede to tying the benefits to a <a href="http://presspass.nbcnews.com/_news/2012/11/11/15089281-white-house-grand-bargain-offer-to-speaker-boehner-obtained-by-bob-woodward#.UKCJftkTtS8.twitter" target="_hplink">recalculated Consumer Price Index</a> that would ultimately provide less money to retirees. Sen. Bernie Sanders claims that, under such a measure, seniors who are currently 65 years-old would see their benefits drop by <a href="http://thehill.com/homenews/senate/267079-reid-assures-sanders-he-wont-agree-to-social-security-cuts-in-debt-deal" target="_hplink">$560 a month in 10 years</a> and by as much as <a href="http://thehill.com/homenews/senate/267079-reid-assures-sanders-he-wont-agree-to-social-security-cuts-in-debt-deal" target="_hplink">$1,000 in 20 years</a>. The Moment of Truth project (led by the two former co-chairs of the president's deficit reduction commission, former Sen. Alan Simpson (R-Wyo.) and former White House Chief of Staff Erskine Bowles) claims that the recalculated CPI could save as much as <a href="http://www.inthesetimes.com/article/11767/the_social_security_cut_washington_does_not_want_you_to_understand/" target="_hplink">$112 billion</a> from Social Security over the next ten years.

  • Tax Loopholes And Deductions - Up To $180 Billion

    Although Cantor and other GOP House members demanded that any deficit-reduction deal brokered in 2011 be classified as <a href="http://www.huffingtonpost.com/2012/11/11/fiscal-cliff-talks-medicare-social-security_n_2113259.html" target="_hplink">revenue-neutral</a>, they were open to closing particular loopholes in the corporate tax code and limiting itemized deductions for individuals -- given that they were offset by other tax cuts. Out of the $50 billion in savings to be found over the next decade from closing loopholes, Cantor proposed getting $3 billion from eliminating the break for corporate-jet owners and another $20 billion from voiding the subsidies for the oil and gas industries. On the individual earner side, he proposed eliminating the second-home mortgage deduction for $20 billion, as well as limiting the mortgage deduction for higher-income households to rake in another $20 billion. He also offered to tighten the tax treatment of retirement accounts. But Democrats wanted to see even greater action taken on itemized deductions. In June 2011, Rep. Chris Van Hollen (D-Md.) proposed raising $130 billion in new revenues by capping itemized deductions at 35 percent for the highest income brackets. The GOP response to his proposal at the time was a resounding "no."

  • Bush Tax Cuts For The Wealthy - $950 Billion

    Set to expire on Dec. 31, 2012, the Bush tax cuts represent one of the most controversial elements of the so-called fiscal cliff. They added over <a href="http://graphics8.nytimes.com/images/2011/07/24/opinion/sunday/24editorial_graph2/24editorial_graph2-popup.gif" target="_hplink">$1.8 trillion to the deficit</a> between 2002 and 2009. Yet Republicans argue that an extension is necessary to create jobs and spur economic growth. But a <a href="http://tpmdc.talkingpointsmemo.com/PDF/0915taxesandeconomy.pdf" target="_hplink">study</a> from the Congressional Research Service found that tax cuts for the wealthiest earners had little economic effect. The White House is pushing for a renewal only of those tax breaks for the lower- and middle-class Americans in order to save the average middle-class family <a href="http://money.cnn.com/2012/10/01/pf/taxes/fiscal-cliff-tax/index.html" target="_hplink">between $2,000 and $3,500</a> next year. Letting the cuts expire for those earning over $250,000 a year -- or the wealthiest two percent of Americans -- would haul in <a href="http://www.offthechartsblog.org/cbo-ending-high-income-tax-cuts-would-save-almost-1-trillion/" target="_hplink">$950 billion</a> in savings over the next decade, according to the CBO. Obama stressed how much the country stood to gain from such an approach Wednesday during a press conference. "If we right away say 98 percent of Americans are not going to see their taxes go up ? 97 percent of small businesses are not going to see their taxes go up," he said. "If we get that in place, we're actually <a href="http://www.cnbc.com/id/49821777" target="_hplink">removing half of the fiscal cliff</a>."

  • Source: http://www.huffingtonpost.com/2012/12/27/fiscal-cliff-talks_n_2372571.html

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    Video: Little evidence of deal-making on "fiscal cliff" (cbsnews)

    Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

    Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/273499682?client_source=feed&format=rss

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    Thursday, December 27, 2012

    Homes for the homeless: a smart investment in dignity

    Despite a recent rise in poverty, homelessness is down. One reason? Providing a residence for the homeless creates enough self-respect for them to deal with underlying issues.

    By the Monitor's Editorial Board / December 26, 2012

    Al Horne looks up at the rain falling on homeless people waiting in line to receive a Christmas meal by The Extended Aftercare Alumni volunteers on Christmas morning in downtown Houston. Volunteers distributed a holiday meal, clothes, and hygiene gift packages on Christmas morning in a tradition started to give people new to recovery from drug and alcohol addiction an opportunity to be of service.

    Mayra Beltran/Houston Chronicle/AP Photo

    Enlarge

    Two decades ago, a simple idea was floated in the United States: Give homeless people a home rather then temporary shelter and their sense of personal dignity will rise, opening the way for them to solve their problems.?

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    The idea finally spread nationwide under President George W. Bush and has been enhanced by President Obama. This has led to an amazing result: Despite the drop in personal income and a rise in poverty caused by the 2007-09 recession, homelessness has dropped in recent years, according to new data.

    The reasons now seem obvious. People who aren?t living on the streets or in temporary settings have better stability to deal with mental, drug, or family problems that often go hand in hand with homelessness. They don?t cycle in and out of hospitals, mental-health facilities, jails, courts, or shelters at great expense to taxpayers. They are not socially stigmatized by their living conditions. A home helps center them.

    For charities and government, the cost savings of this ?housing first? strategy have been a significant incentive to keep funding it. In 2010, the Obama administration even began to believe it could completely whip homelessness. It set a goal to end ?chronic? homelessness by 2015 (or not have any individuals who have been homeless for a year or more or have had at least four episodes of homelessness in the past three years). It set the same goal for homeless veterans. But it set a less ambitious date of 2020 to end homelessness for families, youth, and children.

    The goals may not be met by those dates but that should not discourage efforts to give those struggling with homelessness the self-respect and stability that helps them keep off the streets. The next nationwide survey of the homeless population will be on the night of Jan. 28-29, offering yet another possible marker on recent progress.

    ?We know that combining permanent housing with a coordinated pipeline of supportive services is the best way to help people improve their lives and avoid future homelessness,? said Secretary of Health and Human Services Kathleen Sebelius in a recent speech.

    Despite the nationwide results, many cities with the worst homelessness are worried about the future. A December survey by the US Conference of Mayors showed that homeless families with children were denied shelter this year in more than half of these cities because of inadequate capacity. The cities expect an increase in demand for shelter in 2013.

    When a good idea works in addressing a social ill, both liberals and conservatives can often rally around it. They did so on welfare reform in 1996 and again on the ?housing first? strategy. Opinions may differ on funding levels or the degree of private versus government contributions, but good reform ideas can find a permanent home in society.

    Source: http://rss.csmonitor.com/~r/feeds/csm/~3/ES_b_4PsMUo/Homes-for-the-homeless-a-smart-investment-in-dignity

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    Strange behavior: New study exposes living cells to synthetic protein

    Strange behavior: New study exposes living cells to synthetic protein [ Back to EurekAlert! ] Public release date: 27-Dec-2012
    [ | E-mail | Share Share ]

    Contact: Richard Harth
    richard.harth@asu.edu
    Arizona State University

    One approach to understanding components in living organisms is to attempt to create them artificially, using principles of chemistry, engineering and genetics. A suite of powerful techniquescollectively referred to as synthetic biologyhave been used to produce self-replicating molecules, artificial pathways in living systems and organisms bearing synthetic genomes.

    In a new twist, John Chaput, a researcher at Arizona State University's Biodesign Institute and colleagues at the Department of Pharmacology, Midwestern University, Glendale, AZ have fabricated an artificial protein in the laboratory and examined the surprising ways living cells respond to it.

    "If you take a protein that was created in a test tube and put it inside a cell, does it still function," Chaput asks. "Does the cell recognize it? Does the cell just chew it up and spit it out?" This unexplored area represents a new domain for synthetic biology and may ultimately lead to the development of novel therapeutic agents.

    The research results, reported in the advanced online edition of the journal ACS Chemical Biology, describe a peculiar set of adaptations exhibited by Escherichia coli bacterial cells exposed to a synthetic protein, dubbed DX. Inside the cell, DX proteins bind with molecules of ATP, the energy source required by all biological entities.

    "ATP is the energy currency of life," Chaput says. The phosphodiester bonds of ATP contain the energy necessary to drive reactions in living systems, giving up their stored energy when these bonds are chemically cleaved. The depletion of available intracellular ATP by DX binding disrupts normal metabolic activity in the cells, preventing them from dividing, (though they continue to grow).

    After exposure to DX, the normally spherical E. coli bacteria develop into elongated filaments. Within the filamentous bacteria, dense intracellular lipid structures act to partition the cell at regular intervals along its length (see figure 1). These unusual structures, which the authors call endoliposomes, are an unprecedented phenomenon in such cells.

    "Somewhere along the line of this filamentation, other processes begin to happen that we haven't fully understood at the genetic level, but we can see the results phenotypically," Chaput says. "These dense lipid structures are forming at very regular regions along the filamented cell and it looks like it could be a defense mechanism, allowing the cell to compartmentalize itself." This peculiar adaptation has never been observed in bacterial cells and appears unique for a single-celled organism.

    Producing a synthetic protein like DX, which can mimic the elaborate folding characteristics of naturally occurring proteins and bind with a key metabolite like ATP is no easy task. As Chaput explains, a clever strategy known as mRNA display was used to produce, fine-tune and amplify synthetic proteins capable of binding ATP with high affinity and specificity, much as a naturally occurring ATP-binding protein would.

    First, large libraries of random sequence peptides are formed from the four nucleic acids making up DNA, with each strand measuring around 80 nucleotides in length. These sequences are then transcribed into RNA with the help of an enzymeRNA polymerase. If a natural ribosome is then introduced, it attaches to the strand and reads the random sequence RNA as though it was a naturally-occurring RNA, generating a synthetic protein as it migrates along the strand. In this way, synthetic proteins based on random RNA sequences can be generated.

    Exposing the batch of synthetic proteins to the target molecule and extracting those that bind can then select for ATP-binding proteins. But as Chaput explains, there's a problem: "The big question is how do you recover that genetic information? You can't reverse transcribe a protein back into DNA. You can't PCR amplify a protein. So we have to do all these molecular biology tricks."

    The main trick involves an earlier step in the process. A molecular linker is chemically attached to the RNA templates, such that each RNA strand forms a bond with its newly translated protein. The mRNA-protein hybrids are exposed to selection targets (like ATP) over consecutive rounds of increasing stringency. After each round of selection, those library members that remain bound to the target are reverse-transcribed into cDNA (using their conveniently attached RNA messages), and then PCR amplified.

    In the current study, E. coli cells exposed to DX transitioned into a filamentous form, which can occur naturally when such cells are subject to conditions of stress. The cells display low metabolic activity and limited cell division, presumably owing to their ATP-starved condition.

    The study also examined the ability of E. coli to recover following DX exposure. The cells were found to enter a quiescent state known as viable but non-culturable (VBNC), meaning that they survived ATP sequestration and returned to their non-filamentous state after 48 hours, but lost their reproductive capacity. Further, this condition was difficult to reverse and seems to involve a fundamental reprogramming of the cell.

    In an additional response to DX, the filamentous cells form previously undocumented structures, which the authors refer to as endoliposomes. These dense lipid concentrations, spanning the full width of the filamented E. coli, segment the cells into distinct compartments, giving the cells a stringbean-like appearance under the microscope.

    The authors speculate that this adaptation may be an effort to maintain homeostasis in regions of the filamentous cell, which have essentially been walled off from the intrusion of ATP-depleting DX. They liken endoliposomes to the series of water-tight compartments found in submarines which are used to isolate damaged sections of the ship and speculate that DX-exposed cells are partitioning their genetic information into regions where it can be safely quarantined. Such self-compartmentalization is known to occur in some eukaryotic cells, but has not been previously observed in prokaryotes like E. coli.

    The research indicates that there is still a great deal to learn about bacterial behavior and the repertoire of responses available when such cells encounter novel situations, such as an unfamiliar, synthetic protein. The study also notes that many infectious agents rely on a dormant state, (similar to the VBNC condition observed in the DX-exposed E. coli), to elude detection by antibiotics. A better understanding of the mechanisms driving this behavior could provide a new approach to targeting such pathogens.

    The relative safety of E. coli as a model organism for study may provide a fruitful tool for more in-depth investigation of VBNC states in pathogenic organisms. Further, given ATP's central importance for living organisms, its suppression may provide another avenue for combating disease. One example would be an engineered bacteriophage capable of delivering DX genes to pathogenic organisms.

    ###

    In addition to his appointment at the Biodesign Institute, John Chaput is an associate professor in the Department of Chemistry and Biochemistry, in the College of Liberal Arts & Sciences

    Written by Richard Harth
    Science Writer: The Biodesign Institute
    richard.harth@asu.edu


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    Strange behavior: New study exposes living cells to synthetic protein [ Back to EurekAlert! ] Public release date: 27-Dec-2012
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    Contact: Richard Harth
    richard.harth@asu.edu
    Arizona State University

    One approach to understanding components in living organisms is to attempt to create them artificially, using principles of chemistry, engineering and genetics. A suite of powerful techniquescollectively referred to as synthetic biologyhave been used to produce self-replicating molecules, artificial pathways in living systems and organisms bearing synthetic genomes.

    In a new twist, John Chaput, a researcher at Arizona State University's Biodesign Institute and colleagues at the Department of Pharmacology, Midwestern University, Glendale, AZ have fabricated an artificial protein in the laboratory and examined the surprising ways living cells respond to it.

    "If you take a protein that was created in a test tube and put it inside a cell, does it still function," Chaput asks. "Does the cell recognize it? Does the cell just chew it up and spit it out?" This unexplored area represents a new domain for synthetic biology and may ultimately lead to the development of novel therapeutic agents.

    The research results, reported in the advanced online edition of the journal ACS Chemical Biology, describe a peculiar set of adaptations exhibited by Escherichia coli bacterial cells exposed to a synthetic protein, dubbed DX. Inside the cell, DX proteins bind with molecules of ATP, the energy source required by all biological entities.

    "ATP is the energy currency of life," Chaput says. The phosphodiester bonds of ATP contain the energy necessary to drive reactions in living systems, giving up their stored energy when these bonds are chemically cleaved. The depletion of available intracellular ATP by DX binding disrupts normal metabolic activity in the cells, preventing them from dividing, (though they continue to grow).

    After exposure to DX, the normally spherical E. coli bacteria develop into elongated filaments. Within the filamentous bacteria, dense intracellular lipid structures act to partition the cell at regular intervals along its length (see figure 1). These unusual structures, which the authors call endoliposomes, are an unprecedented phenomenon in such cells.

    "Somewhere along the line of this filamentation, other processes begin to happen that we haven't fully understood at the genetic level, but we can see the results phenotypically," Chaput says. "These dense lipid structures are forming at very regular regions along the filamented cell and it looks like it could be a defense mechanism, allowing the cell to compartmentalize itself." This peculiar adaptation has never been observed in bacterial cells and appears unique for a single-celled organism.

    Producing a synthetic protein like DX, which can mimic the elaborate folding characteristics of naturally occurring proteins and bind with a key metabolite like ATP is no easy task. As Chaput explains, a clever strategy known as mRNA display was used to produce, fine-tune and amplify synthetic proteins capable of binding ATP with high affinity and specificity, much as a naturally occurring ATP-binding protein would.

    First, large libraries of random sequence peptides are formed from the four nucleic acids making up DNA, with each strand measuring around 80 nucleotides in length. These sequences are then transcribed into RNA with the help of an enzymeRNA polymerase. If a natural ribosome is then introduced, it attaches to the strand and reads the random sequence RNA as though it was a naturally-occurring RNA, generating a synthetic protein as it migrates along the strand. In this way, synthetic proteins based on random RNA sequences can be generated.

    Exposing the batch of synthetic proteins to the target molecule and extracting those that bind can then select for ATP-binding proteins. But as Chaput explains, there's a problem: "The big question is how do you recover that genetic information? You can't reverse transcribe a protein back into DNA. You can't PCR amplify a protein. So we have to do all these molecular biology tricks."

    The main trick involves an earlier step in the process. A molecular linker is chemically attached to the RNA templates, such that each RNA strand forms a bond with its newly translated protein. The mRNA-protein hybrids are exposed to selection targets (like ATP) over consecutive rounds of increasing stringency. After each round of selection, those library members that remain bound to the target are reverse-transcribed into cDNA (using their conveniently attached RNA messages), and then PCR amplified.

    In the current study, E. coli cells exposed to DX transitioned into a filamentous form, which can occur naturally when such cells are subject to conditions of stress. The cells display low metabolic activity and limited cell division, presumably owing to their ATP-starved condition.

    The study also examined the ability of E. coli to recover following DX exposure. The cells were found to enter a quiescent state known as viable but non-culturable (VBNC), meaning that they survived ATP sequestration and returned to their non-filamentous state after 48 hours, but lost their reproductive capacity. Further, this condition was difficult to reverse and seems to involve a fundamental reprogramming of the cell.

    In an additional response to DX, the filamentous cells form previously undocumented structures, which the authors refer to as endoliposomes. These dense lipid concentrations, spanning the full width of the filamented E. coli, segment the cells into distinct compartments, giving the cells a stringbean-like appearance under the microscope.

    The authors speculate that this adaptation may be an effort to maintain homeostasis in regions of the filamentous cell, which have essentially been walled off from the intrusion of ATP-depleting DX. They liken endoliposomes to the series of water-tight compartments found in submarines which are used to isolate damaged sections of the ship and speculate that DX-exposed cells are partitioning their genetic information into regions where it can be safely quarantined. Such self-compartmentalization is known to occur in some eukaryotic cells, but has not been previously observed in prokaryotes like E. coli.

    The research indicates that there is still a great deal to learn about bacterial behavior and the repertoire of responses available when such cells encounter novel situations, such as an unfamiliar, synthetic protein. The study also notes that many infectious agents rely on a dormant state, (similar to the VBNC condition observed in the DX-exposed E. coli), to elude detection by antibiotics. A better understanding of the mechanisms driving this behavior could provide a new approach to targeting such pathogens.

    The relative safety of E. coli as a model organism for study may provide a fruitful tool for more in-depth investigation of VBNC states in pathogenic organisms. Further, given ATP's central importance for living organisms, its suppression may provide another avenue for combating disease. One example would be an engineered bacteriophage capable of delivering DX genes to pathogenic organisms.

    ###

    In addition to his appointment at the Biodesign Institute, John Chaput is an associate professor in the Department of Chemistry and Biochemistry, in the College of Liberal Arts & Sciences

    Written by Richard Harth
    Science Writer: The Biodesign Institute
    richard.harth@asu.edu


    [ Back to EurekAlert! ] [ | E-mail | Share Share ]

    ?


    AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


    Source: http://www.eurekalert.org/pub_releases/2012-12/asu-sbn122712.php

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